Ionomycin, a new polyether antibiotic with a high affinity for calcium ions, is obtained in pure form from fermentation broths of Streptomyces conglobatus sp. nov. Trejo by solvent extraction. It is unique amongst known polyether antibiotics in that it has a UV absorption maximum at 300 nm. thereby distinguishing it from other antibiotics of its class. The Ca salt has the molecular formula C41H70O9Ca. Ionomycin is a narrow spectrum antibiotic being active against Gram-positive bacteria.
Kusakabe Y, Mizuno T, Kawabata S, Tanji S, Seino A, Seto H, Otake N. Kusakabe Y, et al. J Antibiot (Tokyo). 1982 Sep;35(9):1119-29. doi: 10.7164/antibiotics.35.1119. J Antibiot (Tokyo). 1982. PMID: 7142018
Ohshima M, Ishizaki N, Abe N, Ukawa M, Marumoto Y. Ohshima M, et al. J Antibiot (Tokyo). 1976 Apr;29(4):354-65. doi: 10.7164/antibiotics.29.354. J Antibiot (Tokyo). 1976. PMID: 931804
Omura S, Shibata M, Machida S, Sawada J. Omura S, et al. J Antibiot (Tokyo). 1976 Jan;29(1):15-20. doi: 10.7164/antibiotics.29.15. J Antibiot (Tokyo). 1976. PMID: 931790
Westley JW. Westley JW. Adv Appl Microbiol. 1977;22:177-223. doi: 10.1016/s0065-2164(08)70163-1. Adv Appl Microbiol. 1977. PMID: 337768 Review. No abstract available.
O'Hagan D. O'Hagan D. Nat Prod Rep. 1989 Apr;6(2):205-19. doi: 10.1039/np9890600205. Nat Prod Rep. 1989. PMID: 2664585 Review. No abstract available.
Pang J, Yu Q, Chen Y, Yuan H, Sheng M, Tang W. Pang J, et al. J Transl Med. 2022 Nov 18;20(1):531. doi: 10.1186/s12967-022-03723-x. J Transl Med. 2022. PMID: 36401283 Free PMC article.
Tharappel AM, Li Z, Zhu YC, Wu X, Chaturvedi S, Zhang QY, Li H. Tharappel AM, et al. ACS Infect Dis. 2022 Sep 9;8(9):1851-1868. doi: 10.1021/acsinfecdis.2c00137. Epub 2022 Aug 10. ACS Infect Dis. 2022. PMID: 35948057 Free PMC article.
Dembitsky VM. Dembitsky VM. Mar Drugs. 2022 Apr 26;20(5):292. doi: 10.3390/md20050292. Mar Drugs. 2022. PMID: 35621943 Free PMC article. Review.
Konig MF, Andrade F. Konig MF, et al. Front Immunol. 2016 Nov 4;7:461. doi: 10.3389/fimmu.2016.00461. eCollection 2016. Front Immunol. 2016. PMID: 27867381 Free PMC article.
Adrian J, Gross LJ, Stark CBW. Adrian J, et al. Beilstein J Org Chem. 2016 Sep 30;12:2104-2123. doi: 10.3762/bjoc.12.200. eCollection 2016. Beilstein J Org Chem. 2016. PMID: 27829917 Free PMC article. Review.